pentobarbital will reduce the extent or influence of ethotoin by impacting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Check.pentobarbital will lessen the extent or impact of itraconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unfamiliar.pentobarbital will reduce the extent or impact of lorlatinib by